Endocrine Abstracts

Introduction: In the search for markers of invasiveness of pituitary adenomas, we studied the expression of Ki-67 antigen, TOPO 2A (topoisomerase 2 alpha), AIP (Aryl Hydrocarbon Receptor-Interacting Protein), and VEGF (Vascular Endothelial Growth Factor) in somatotropinomas.Material and methods: We studied retrospectively a group of 31 patients (20 female, 11 male) of mean age 43.3±14.3 years who underwent pituitary tumour surgery. Expression of Ki-...

We evaluated the volume of pituitary adenoma in patients treated with ocreotide LAR (SSLAR) prior to surgery.Materials and methods: Twenty-six patients (22 females and 4 males, mean age 57.5±15.0 years) were treated with SSLAR: 5 patients with microadenoma – during 6 months, and 21 patients with macroadenoma – during 12 months before surgery, as recommended by the Polish Society of Endocrinology. Concentration of hGH and IGF1 was evaluated...

Treatment of acromegalic patients with somatostatin analogues decreases hGH and IGF1 concentrations, improves general and metabolic conditions and decreases morbidity and mortality in these patients. We assessed the efficacy of octreotide LAR (SSLAR) in treating acromegalic patients following non-radical surgery of pituitary adenoma at a single centre.Materials and methods: At our Centre we follow 85 acromegalic patients who underwent surgery, including ...

Background: Somatostatin analogues are used to treat acromegaly patients who, following surgery, have not fulfilled cure criteria (hGH<2,5 ng/ml, IGF-1 below normal range for age and post-OGTT hGH <1,0 ng/ml). We evaluated the efficacy of Sandostatin LAR in managing such patients.Material and method: In our Clinic, 81 acromegaly patients (mean age 51.6±14.4 yrs) were registered over the years 1983-2005. Based on CT i MRI, macroadenoma and mi...

Introduction: Treatment with somatostatin analogues (SSA) leads to shrinkage of pituitary adenoma in acromegaly naïve patients, as shown by the PRIMARYS study. Therefore the effect of this treatment on surgery was investigated.Aim: To evaluate the efficacy of pre-treatment with SSA in acromegaly patients qualified for neurosurgery.Material and methods: Group A (46 patients: 36 female, 10 male) were pre-treated with SSA. Group ...

Introduction: It has been shown that thyroid cancer has a significant correlation with cancers originated from other organs. The aim of this study was to investigate the association between synchronous primary cancers in patients with thyroid cancer.Material and Method: A retrospective analysis of medical records of 560 thyroid cancer patients treated in the years 2007–2013 and followed up over 2–8 years, was performed. In 38 patients (6.7%), 5...

Introduction: Based on cancer registries, the risk of second primary malignancies in patients with DTC increases by 30%. In our case report we aimed at understanding the patomechanism of metachronous primary tumours in patients with thyroid cancer.Case: In a 71-year old female surgery of nodular goitre (1988), followed by papillary thyroid cancer (pT3NxMx) surgery (2008) and complementary 131-I treatment (2009), were performed. In diagnostic WBS (2010) n...

Introduction: In treating hyperthyroidism in Graves’ disease (GD) patients with 131-iodine, the optimum activity of radioiodide is yet to be established. We analysed factors affecting the efficacy of 131I radiotherapy in GD patients.Materials and methods: The analysed group consisted of 362 (80.9% females and 19.1% males) GD patients, of median age 53 (min: 14 and max: 85) years. GD was diagnosed from clinical features, laboratory tests, ...

Introduction: As observed clinically, the development of pituitary tumours and the probability of their recurrence after neurosurgery tend to be unpredictable. The aim of this work was to evaluate Ki-67 and nuclear and plasmatic prothymosin alpha indices as potential pathological markers to predict the aggressiveness of pituitary adenomas.Material and methods: Ki-67 and prothymosin alpha indices were determined by immunochemistry in specimens excised fro...

Introduction: During clinical observation the behaviour of pituitary tumours is often unpredictable. The work was aimed at evaluating Ki-67 and pituitary tumour transforming gene (PTTG) indices in pituitary adenomas.Material and methods: The Ki-67 and PTTG indices were determined by immunochemistry in specimens excised from neurosurgically removed pituitary tumours. In fifty two examined patients (30 females and 22 males, mean age 50.5±15.4 years) w...